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concern re: Metformin manufacturer change?

Question:
Since being diagnosed with Type 2 approx 18 months ago, I had been taking the same generic 500mg metformin with good results. All I can tell you about that particular medication is that it is a white, round pill with the letters I45.
My last renewal is from a different manufacturer: Zydus Pharm - a white, round pill with a "Z" on one side and the number "70" on the other side.
I described these pills because I don't seem to be getting the same effect on my glucose level with this new pill. Is it possible that different manufacturers could provide the same basic pill with different results?
Any information that someone could give me, or direct me to, would certainly be appreciated. Thank you.
Answers:
Generic manufacturers are allowed to meet FDA bioequivalence as long as their product contains 80-125% of the stated dosage. This could result in varying effects. For this reason one particular diabetologist prescribes only Glucophage for his patients because off the less-than-predictable results seen in his patients on generic metformin.
Answers:
It's possible it may not work as well. If that's the case, switch to the brand-name Glucophage.
Nicole
Answers:
When I fill my prescriptions, I find the pharmacy often changes suppliers. All it says on the bottle is the generic name , not the manufacturer. I do find some prescriptions seem less effective than others.
Answers:
I follow Dr. Bernstein and he states in his book, Diabetes Solution, and during most of his teleconferences that the brand name, Glucophage, works much better than the generic.
So, even tho the brand name is more expensive, I switched. And I think my numbers really are better with the brand name version.
Answers:
Usually the manufacturer's name is on the bottle, if it's not you can find out by asking the pharmacy. If you find one works better than another, you can ask the pharmacy for that manufacturer. I had a problem with a med I took years ago when pharmacy gave me the generic from another drug company. I mentioned it to the pharmacist and she got me the generic from the other company that worked better for me.
Nicole
Answers:
Thanks for the input. I was able to find the mfgr for the old meds and will ask the pharmacy to refill my scripts with that one. Thanks again. The members on
this website are always there if I need them.
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